Pharmacy Resident MUSC Charleston, South Carolina, United States
Poster Abstract:
Background: Chemotherapy induced peripheral neuropathy (CIPN) is a disabling side effect of certain chemotherapy agents resulting in peripheral nerve damage and commonly manifesting as numbness, tingling, or pain in a patient’s fingers or toes.1 Associated chemotherapy agents include platinum agents, taxanes, and vinca alkaloids. The incidence is as high as 68% in the first month after chemotherapy initiation, 60% at 3 months, and 30% at 6 months or more.2 Uncontrolled CIPN may require chemotherapy dose reductions, delays, or cessation, leading to an increase in cancer related morbidity and mortality. Therefore, proper identification and management are imperative.3
Objectives: The primary objective is to describe current pharmacologic management of CIPN across multiple cancer types at an academic medical center. Secondary endpoints include assessing the percentage of patients who developed CIPN, received non-pharmacologic or pharmacologic treatment, and completion of desired number of chemotherapy cycles in order to standardize institutional practices.
Methods: Retrospective chart review of solid tumor patients who initiated and received at least 2 consecutive administrations of any of the following: carboplatin, cisplatin, oxaliplatin, vincristine, vinblastine, paclitaxel, or docetaxel between January and March of 2023 at the Medical University of South Carolina. Patients were excluded if they were pregnant, participating in a clinical trial, had pre-existing neurological conditions, missing data points, received chemotherapy at an outside institution, had baseline peripheral neuropathy, or had been on any of the following prior to chemotherapy initiation: gabapentin, duloxetine, pregabalin, cannabis oil, B vitamin complex, amitriptyline, doxepin, nortriptyline, or venlafaxine.
Results: In progress
Conclusions: In progress
References (must also be included in final poster): 1. National Cancer Institute. Cancer Treatment. Side Effects of Cancer Treatment. Nerve Problems (Peripheral Neuropathy) and Cancer Treatment. Accessed December 11, 2023. https://www.cancer.gov/about-cancer/treatment/side-effects/nerve-problems
2. Seretny M, Currie GL, Sena ES, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain. 2014;155(12):2461-2470. doi:10.1016/j.pain.2014.09.020.
3. Burgess J, Ferdousi M, Gosal D, et al. Chemotherapy-Induced Peripheral Neuropathy: Epidemiology, Pathomechanisms and Treatment. Oncol Ther. 2021;9(2):385-450. doi:10.1007/s40487-021-00168-y.
